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  • Diagnosis and Management of Acute Heart Failure in the Emergency Department

    This article will focus on the care of patients with acute heart failure in the emergency department, reviewing new onset and decompensation of chronic heart failure, discussing heart failure classification based on clinical presentation, and providing updated recommendations on management and disposition from the emergency department.

  • Infectious Disease Alert Updates

    The Burden of Clostridioides difficile Infection; The Globe May Be Warming, but People Are Cooler; Methotrexate for Chikungunya Arthritis

  • Nirmatrelvir-Ritonavir in High-Risk Vaccinated and Low-Risk Unvaccinated Participants: The EPIC-SR Trial

    In this Phase II-III randomized controlled clinical trial (EPIC-SR), nirmatrelvir-ritonavir was not associated with a significant difference in time to alleviation of symptoms nor COVID-19-related hospitalization or death from any cause as compared with placebo in unvaccinated individuals without risk factors for severe disease or in vaccinated individuals with a least one risk factor for severe disease.

  • Avian Flu Rears Its Beak Again in the United States

    The Centers for Disease Control and Prevention has issued an alert after a human infection with highly pathogenic avian influenza (HPAI) A(H5N1) virus in the United States following exposure to presumed infected dairy cattle. No human-to-human transmission of HPAI A(H5N1) virus has been identified.

  • High-Mortality Cryptococcosis Infection After COVID-19

    A survey initiated by the Mycoses Study Group identified 69 cases of cryptococcosis following COVID-19 infection. The mortality rate was 59%, with cases in both immunocompromised and immunocompetent individuals.

  • Meningococcal Disease Is on the Rise

    The number of cases of infection with Neisseria meningitidis is increasing in the United States. The majority of presentations are with bacteremia; meningitis is infrequent.

  • More than Half of 2024 Measles Cases Hospitalized

    A measles outbreak continues to hit Chicago, while surveillance nationally found 113 cases in 18 states as of April 4, 2024. With cases both in the community and in migrant shelters, the Chicago Health Department reported 61 measles infections as of April 11, 2024.

  • Predicting Outcomes of Congenital Cytomegalovirus Infection

    Congenital cytomegalovirus infection can cause hearing loss and neurologic deficits, but most affected newborns escape without sequelae. New data suggest a good prognosis if the mother’s infection was after the first trimester and if the newborn has normal hearing, a normal platelet count, and a normal head ultrasound exam.

  • CDC Issues Alert on Spike in Meningitis

    Infection preventionists should be aware of increasing cases of invasive Neisseria meningitidis, which currently are causing an 18% mortality rate and primarily infecting three risk groups: Black people, people with human immunodeficiency virus, and those in the age range of 30 to 60 years, the Centers for Disease Control and Prevention reports in a public health alert.

  • All In: If You Share Patients, Collaborate

    A regional decolonization collaborative among hospitals and long-term care facilities that commonly share patients led to decreased infections, hospitalizations, costs, and deaths caused by multidrug-resistant organisms, researchers reported.